Mycophenolate mofetil: a magic bullet for lupus?
نویسندگان
چکیده
منابع مشابه
Mycophenolate mofetil for induction therapy of lupus nephritis: a systematic review and meta-analysis.
BACKGROUND AND OBJECTIVES Although the accepted standard of care for induction of lupus nephritis has been cyclophosphamide, recent trials suggest that mycophenolate mofetil may be as or more effective and less toxic. A systematic review and meta-analysis were performed to determine the risk for failure to induce remission of lupus nephritis in patients who were treated with mycophenolate mofet...
متن کاملLupus nephritis: induction therapy in severe lupus nephritis--should MMF be considered the drug of choice?
Severe lupus nephritis is an aggressive disease that requires an aggressive approach to treatment. Recent randomized clinical trials showed that mycophenolate mofetil compared favorably with cyclophosphamide (traditional approach) for remission induction. Consequently, mycophenolate mofetil is now commonly recommended as first-line therapy. Nevertheless, the role of mycophenolate mofetil in tre...
متن کاملMycophenolate mofetil versus cyclophosphamide for therapy of lupus nephritis: an evidence-based case report from systematic reviews and meta- analyses
Background: The aim of this case study is to compare the effectiveness between cyclophosphamide and mycophenolate mofetil to achieve remission of lupus nephritis in an evidence-based case report from meta-analyses. Methods: Method in this case study is evidence-based case report using meta-analyses. Clinical question used in this paper is; which immunosuppressant gives better result in achievin...
متن کاملMycophenolate versus azathioprine as maintenance therapy for lupus nephritis.
BACKGROUND Maintenance therapy, often with azathioprine or mycophenolate mofetil, is required to consolidate remission and prevent relapse after the initial control of lupus nephritis. METHODS We carried out a 36-month, randomized, double-blind, double-dummy, phase 3 study comparing oral mycophenolate mofetil (2 g per day) and oral azathioprine (2 mg per kilogram of body weight per day), plus...
متن کاملThe development of membranous lupus nephritis during treatment with mycophenolate mofetil for proliferative renal disease
The transformation of lupus nephritis from one histologic pattern to another is well described. We report a case of a patient who initially presented with diffuse proliferative glomerulonephritis and was treated with prednisone and mycophenolate mofetil (MMF). She initially responded well to therapy, but later developed high-grade proteinuria while still on MMF and low-dose steroids. A repeat b...
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ورودعنوان ژورنال:
- The Journal of rheumatology
دوره 32 6 شماره
صفحات -
تاریخ انتشار 2005